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Ibutamoren mesylate, MK-677

What is Ibutamoren?

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Ibutamoren mesylate, also known as MK-677, is an orally active non peptide growth hormone (GH) secretagogue, which stimulates growth hormone (GH) release through a pituitary and hypothalamic receptor that is different from the GH-releasing hormone receptor. Clinically, it has been demonstrated to increase the endogenous release of growth hormone (GH) as well as insulin-like growth factor 1 (IGF-1) without the adverse increase of prolactin or cortisol often seen with GHRPs. Additionally, increases in lean body mass can be achieved while lowering LDL cholesterol. Talk to our medical experts.

Research Behind Ibutamoren

Studies have shown Ibutamoren stimulates brain regions involved with metabolic action, such as the hypothalamus and the pituitary. Ibutamoren may be effective in increasing both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty and osteoporosis in the elderly. Ibutamoren also aids in wound healing, tissue regeneration and improves sleep. 

An affiliated study with Merck Research Laboratories stated growth hormone (GH) stimulates osteoblasts in vitro and increases bone turnover and stimulates osteoblast activity when given to elderly subjects. Probably a major effect of GH on bone is mediated through stimulation of either circulating or locally produced insulin-like growth factor I (IGF-I). The research determined that once daily dosing with ibutamoren, an orally active GH secretagogue, stimulates bone turnover in elderly subjects based on elevations in biochemical markers of bone resorption and formation. 

Ibutamoren Benefits

1. Helps Build Muscle

Ibutamoren is frequently used as an anabolic substance, to increase lean body mass. It is orally active and can be taken once a day. Ibutamoren stimulates Growth Hormone and IGF-1 which each factor in significantly to maintaining lean body mass. Growth Hormone is believed by many to stimulate an increase in muscle size and strength and the ability of ibutamoren to increase Growth Hormone production make it a popular choice.

One study using 60-year-old men indicated that injections to stimulate Growth Hormones led to increased strength in thigh muscles. In another study of 24 obese men, a two-month treatment with ibutamoren increased lean mass, and transiently increased basal metabolic rate (BMR).

2. Reduces Muscle Wasting

Ibutamoren has shown in recent studies to alleviate muscle wasting that can be caused by a decline in protein within an individual’s diet. In one study a group of healthy young adults were tested to determine if ibutamoren could reverse protein catabolism. The study determined that ibutamoren is theorized to be an effective treatment for individuals who suffer from catabolic conditions. Learn more about medical benefits..

3. Increases Bone Density

Several studies have indicated that long-term use of ibutamoren can have tremendous results to increase bone mineral density. An affiliated study with Merck Research Laboratories stated growth hormone (GH) stimulates osteoblasts in vitro and increases bone turnover and stimulates osteoblast activity when given to elderly subjects. Probably a major effect of GH on bone is mediated through stimulation of either circulating or locally produced insulin-like growth factor I (IGF-I). The research determined that once daily dosing with ibutamoren, an orally active GH secretagogue, stimulates bone turnover in elderly subjects based on elevations in biochemical markers of bone resorption and formation.

4. Improves Sleep

Since Growth Hormone is known to help improve sleep quality, it is commonly thought that Ibutamoren Mesylate can assist with sleep quality since it stimulates production of Growth Hormone. A study showed that in both younger and elderly subjects, ibutamoren improved sleep quality, REM (rapid eye movement) and improved sleep duration.

Apart from scientific studies, there have been many reports of subjective improvements in sleep quality from patients at Aspire Rejuvenation Clinic. 

5. Combats Aging and May Increase Longevity

Aging patients taking ibutamoren can benefit greatly since Growth Hormone and IGF-1 can significantly elevate. As we age, our body stops producing as much human growth hormone (HGH) and therefore IGF-1. Human growth hormone is responsible for the development of muscle and bone mass. In fact, the natural production of HGH decreases by around 15% each decade from the age of twenty-five.

Ibutamoren therapy can counteract this decline by stimulating the body to release more HGH, which can lead to an increase in lean muscle mass, a reduction in body fat, increased energy and stamina and a reduction in musculoskeletal inflammation. 

6. Nootropic Effects

Since ibutamoren shares a lot of similar qualities to Ghrelin and binds to its receptors, it is believed that ibutamoren can have the same effects on the brain that Ghrelin has.

There are no studies that confirm ibutamoren has direct nootropic effects on the brain. Scientists theorize ibutamoren may indirectly improve cognitive function through IGF-1 elevation. The ability of Ibutamoren to stimulate IGF-1 production can indirectly improve cognitive function based on IGF-1’s role in cognitive function. One study indicated that IGF-1 positively affected patients’ ability to perform well on cognitive tests. 

 

Potential Side Effects

Reported side effects of ibutamoren are typically the result of unnaturally high levels of growth hormone in the body from taking too much too often, which include increased appetite, lethargy, potential joint pain, insulin resistance and possible increase in prolactin levels. When dosed properly, the side effects of ibutamoren are minimal to none. Schedule a Consultation.

 

References

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Ibutamoren mesylate, MK-677